| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2004 , Vol 46 , Num 2
EFFECTS OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS ON THE THIOL GROUPS AND LIPID PEROXIDATION IN ETHANOL-INDUCED OXIDATIVE STRESS
Inönü University, Faculty of Pharmacy, Dept. of Pharmacology, Malatya
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The aim of this study was to investigate whether nonsteroidal antiinflammatory drugs (NSAlDs) such as ibuprofen (lBU), indomethacin (INDO), aspirin (ASP), and celecoxib (CEL) could enhance the susceptibility the oxidative stress caused by the acute intoxication with .ethanol in gastric mucosa, liver and brain of mice. The results showed that only the IBU treatment contribute to the control of the lipid peroxidation (LPO) andthiol group levels in all tissues. However, CEL can be able to increase the susceptibility of gastric mucosa to ethanol-induced oxidative stress like classic NSAIDs, while it has a significant protective effect in brain tissue ..
Keywords :
NONSTEROIDAL ANTIINFLAMMATORY DRUGS,COX-2 INHIBITORS, LIPID PEROXIDATION, TOTAL THIOL GROUPS, REDUCED GLUTATHIONE