| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2007 , Vol 49 , Num 2
PREPARATION AND IN VITRO EVALUATION OF CEFADROXIL LOADED CHITOSAN MICROSPHERES
Department of Pharmaceutical Technology, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey
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The aim of this study was to prepare cefadroxil (CFD) loaded chitosan microspheres and to investigate the effect of different formulation parameters such as drug-polymer ratio, chitosan concentration, amount of glutaraldehyde and stirring rate on microsphere formation. CFD-loaded chitosan microspheres were prepared by simple coacervation method using glutaraldehyde as cross-linking agent. The particle size, morphological characteristics, thermal behaviour, encapsulation efficiency and in vitro release assessments of the formulations had been carried out. Chitosan microspheres between the size ranges of 4.7-9.8 μm were obtained. The stirring rate was found not effective to particle size of microspheres significantly. Production yield of all formulations was found to be higher than 90% and encapsulation efficiencies of 42-59% were obtained. The decrease of drug:polymer ratio caused an increase in encapsulation efficiency. DSC thermogram showed that the SF was in the crystalline state in the microspheres. In vitro drug release studies indicated that CFD-loaded microspheres showed sustained effect up to 6 weeks. Drug release rates were decreased upon increasing the chitosan concentration and the amount of glutaraldehyde. Drug release was evaluated kinetically and the data was fitted Higuchi kinetic model.
Keywords :
CEFADROXIL, MICROSPHERE, CHITOSAN, SUSTAINED RELEASE, SIMPLE COACERVATION TECHNIQUE