| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2010 , Vol 52 , Num 3
COMPARATIVE EVALUATION OF ZIDOVUDINE TABLETS FORMULATED USING NATURAL AND SEMI SYNTHETIC BINDER
Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore - 641004, India
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Zidovudine is an anti-retroviral drug used in the treatment of AIDS/HIV. Zidovudine tablets were prepared by wet granulation technique using two different binding agents such as hydroxypropylmethylcellulose (semi synthetic binder) and acacia (Natural binder). Formulated tablets were evaluated for hardness, friability, disintegration and weight variation. In vitro release study of the tablets formulated using HPMC shows slow release of drug when compared to tablet with acacia and marketed formulation. Mechanism of release of drug was found to be anomalous type (diffusion followed by erosion) for all the tablet formulations.
Keywords :
ZIDOVUDINE, AIDS, ACACIA, HPMC, HAUSNER RATIO, HIGUCHI MODEL