| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2010 , Vol 52 , Num 3
CHARACTERIZATION AND EVALUATION OF TERMINALIA RANDII GUM AS A BINDER IN CARVEDILOL TABLET FORMULATION
Department of Pharmaceutics and Pharmaceutical Technology, Olabisi Onabanjo University, Sagamu, Nigeria
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The gum exudates obtained from the incised trunk of Terminalia randii (Family Combretaceae) have been evaluated as binding agent in carvedilol tablet formulations in comparison with standard binders - polyvinylpyrrolidone (PVP) and corn starch. The physicochemical properties of the gum was characterized by scanning electron microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), X-ray powder diffraction (XRPD), particle size analysis, pH and viscosity determinations. The mechanical properties of the tablets were assessed using the crushing strength and friability tests while drug release properties were assessed using the disintegration and dissolution times. The crushing strength of the tablets increased while the friability decreased with increase in the concentration of the binding agents. The ranking of the crushing strength of the tablet was formulations containing PVP > Terminalia gum > corn starch while the ranking for friability was the reverse. The disintegration and dissolution times of the tablets also increased with increase in the concentration of the binders. The ranking of the disintegration time was PVP > Terminalia gum > corn starch while the ranking of dissolution time was Terminalia gum > PVP > corn starch. The results indicate that the binding properties of Terminalia gum compared favorably with those of the standard binders and could also find application in controlled release tablet formulations.
Keywords :
TERMINALIA GUM, BINDING AGENT, POLYVINYLPYRROLIDONE, CARVEDILOL, CORN STARCH