| Acceptance rate | 46% |
|---|---|
| Time to first decision | 20 days* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2010 , Vol 52 , Num 4
SYNTHESIS, ANTICONVULSANT ACTIVITY AND COMPARATIVE QSAR STUDY OF SOME NOVEL 1,2,5-TRISUBSTITUTED BENZIMIDAZOLE DERIVATIVES
Lord Shiva College of Pharmacy, Sirsa-125055, Haryana, India
In view of obtaining some potential anticonvulsant compounds we have synthesized a series of 1,2,5- trisubstituted benzimidazoles derivatives (6a-6j, 7a-7j, 8a-8j). The results of QSAR investigation and the study of various physicochemical properties indicates that the change in linker at position one (R1) does not change the activity of the synthesized compounds and optimum chain length at position two (R2) is responsible for the anti-convulsant activity. The results also showed that the synthesized compounds with electron withdrawing group at position five (R3) shows better anti-convulsant activity as predicted by QSAR studies.
Keywords :
SUBSTITUTED BENZIMIDAZOLES; SYNTHESIS; ANTI-CONVULSANT ACTIVITY; QSAR