| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2010 , Vol 52 , Num 4
EFFECT OF KETOCONAZOLE AND JAVA PLUM PRETREATMENT ON INTESTINAL TRANSPORT OF BUSPIRONE ACROSS RAT INTESTINE
Centre for Biopharmaceutics and Pharmacokinetics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, A.P. India
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The effect of ketoconazole and java plum on intestinal transport of buspirone, a CYP3A4 substrate across the rat intestine was investigated using normal sac technique. Three groups of rats, one serves as control; treated with ketoconazole and java plum juice for 7 days respectively in second and third group. The rats were sacrificed and intestinal segments (duodenum, jejunum and ileum) and colon were isolated and used for the studies. The buspirone solution was placed in the isolated intestinal sac. Samples were collected at preset time points and buspirone transported was estimated. The transport of buspirone was increased (p<0.05) 12.5, 5, 5.2 and 5.3 times after pretreatment with ketoconazole; 19.5, 8.5, 10.7 and 7.2 times after pretreatment with java plum juice compared to control. It suggests that both ketoconazole and java plum juice might be acting by inhibiting the transporters and enzymes which are responsible for transport/metabolism of buspirone.
Keywords :
KETOCONAZOLE, JAVA PLUM, BUSPIRONE, NORMAL SAC, INTESTINAL TRANSPORT