| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2010 , Vol 52 , Num 4
SYNTHESIS AND ANTIDIABETIC ACTIVITY OF N’-[3-(ALKYL/ARYL SUBSTITUTED)-4- OXO-1,3 THIAZOLIDIN-2-YEIDENE]-2-(PYRAZIN-2-YLOXY)ACETOHYDRAZIDE
Department of Pharmaceutical Sciences, M.D. University, Rohtak, Haryana-124001, India
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A series of N’-[3-(4-alkayl/arylsubstituted)-4-oxo-1,3thiazolidin-2-ylidene]-2-(pyrazin-2-yloxy) acetohydrazide was synthesized by the cyclization of various N-substituted thiosemicarbazides using chloroacetic acid and sodium acetate in ethanol. Where N-substituted thiosemicarbazone prepared by the reaction of various alkayl/aryl isothiocyanate with 2-(pyrazin-2-yloxy)acetohydrazide, which was synthesized by amination of ethyl(pyrazin-2-yloxy)acetate with hydrazine hydrate. Ethyl(pyrazin-2- yloxy)acetate was prepared from the 2-hydroxypyrazine by ethylchloroacetate under reflux condition. The purity and homogeneity of compounds synthesized were determined by their sharp melting point, TLC, UV, IR, and NMR spectra. The compound N’-[3-(phenyl)-4-oxo-1,3thioazolidin-2-ylidine]-2-(pyrazin-2- yloxy)acetohydrazides, N’-(pyrazin-2-yloxy)acetohydrazide posses good antidiabetic activity with reduced toxicity.
Keywords :
TYPE 2 DIABETES, HYPOGLYCAEMIC, ANTIHYPERGLYCEMIC, GLYCAEMIC, THIAZOLIDINONE