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ACTA Pharmaceutica Sciencia
2005 , Vol 47 , Num 3
EFFECT OF NIFEDIPINE ON THE COLLAR-INDUCED INTIMAL THICKENING AND VASCULAR REACTIVITY CHANGES IN RABBITS
Ege University, Faculty of Pharmacy, Department of Pharmacology, Bornova, Izmir, Turkey
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The positioning of a soft and nonocclusive silicon collar around the rabbit carotid artery induces intimal thickening and characteristic vascular reactivity changes. In the present study, we investigated whether the treatment with nifedipine, a dihydropyridine derivative calcium channel blocker (CCB) (40 mg/kg/day, p.o.), inhibit development of intimal thickening and accompanying vascular reactivity changes in this model. Neither intimal thickening nor vascular reactivity changes were effected by nifedipine treatment in this model.
Keywords :
CALCIUM CHANNEL BLOKER, INTIMAL TICKENING, COLLAR, VASCULAR REACTIVITY