| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2011 , Vol 53 , Num 2
FORMULATION AND EVALUATION OF COLON SPECIFIC DRUG DELIVERY SYSTEM
School of Pharmaceutical Sciences, Shobhit Institute of Engineering and Technology, Modipuram, Meerut (U.P.), India
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The aim of present research work was to develop colon targeted controlled drug delivery system of mesalamine using slight modification in CODESTM technology which protects drug during its passage through the stomach and about first six meters of small intestine. Drug and polymers were directly compressed in tablet press. Mesalamine tablet were prepared in two groups A and B respectively. Group A consisted of combination of carbopol with HPMC and in group B only carbopol was present. Tablets were spray coated with lactulose USP solution, followed with acid-soluble coating material, Eudragit E-100 (10% w/w), water-soluble HPMC (10%w/w), enteric-coating material, Eudragit L-100 (10% w/w). Release of mesalamine from the coated tablets of different batches was studied in 0.1 N HCl (pH of 1.2) for first hour and (PBS) phosphate buffers solution (pH 6.8) for next four hour after that the same tablet was studied for release profile in PBS (pH 5.0). Release profile showed that drug release was possible only in PBS (pH 5.0) i.e. colonic medium. The above test result showed that the enteric and cationic coatings were able to bring the core tablet in colon.
Keywords :
CODESTM TECHNOLOGY, MESALAMINE, COATING POLYMER, EUDRAGIT, COLON TARGETED