| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2011 , Vol 53 , Num 2
BIODEGRADABLE POLYMERIC MICELLES OF CAMPTOTHECIN: FORMULATION AND CHARACTERIZATION
PSG College of Pharmacy, Peelamedu, Coimbatore, Tamilnadu, India
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The purpose of this study was to formulate and characterize biodegradable polymeric micelles (PMs) of diblock copolymers for delivering the anticancer drug camptothecin (CPT) and maintaining its biological activity for a prolonged time. To achieve this, PMs were prepared by emulsification solvent evaporation (ESE) using a rotary flash evaporator (RFE) with the diblock copolymers, methoxy polyethylene glycol-b polycaprolactone (Me PEG-b-PCL) of different molecular weights and loaded with CPT as a model drug. The PMs were evaluated morphologically, and their particle size and critical micelle concentration were determined. In vitro release and in vivo pharmacokinetic studies were also done. The results show that formulating PMs using a long polycaprolactone (PCL) chain increases the entrapment efficiency, loading and stability of CPT and results in slower drug release. This study demonstrates that polyethylene glycol (PEG) and PCL chain length play a crucial role in the in vitro properties of PMs.
Keywords :
METHOXY-POLYETHYLENE GLYCOL-B-POLYCAPROLACTONE, CAMPTOTHECIN, POLYMERIC MICELLES, DIBLOCK COPOLYMERS, CRITICAL MICELLAR CONCENTRATION