| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2011 , Vol 53 , Num 2
EFFECT OF DIFFERENT SALTS ON THE IONOTROPIC GELATION OF PECTIN AND FORMULATION OF ORAL DRUG DELIVERY SYSTEMS BASED ON PECTINATE GELS
Department of Pharmaceutical Technology, Faculty of Pharmacy, Marmara University, Haydarpaşa, Istanbul, Turkey
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The aim of the study was to prepare formulations of oral drug delivery systems based on pectinate gels for controlled release and to find out the effect of the water solubility of the drug loaded. For this purpose pectin beads carrying water soluble drug propranolol hydrochloride and water insoluble drug ketoprofen were prepared by using ionotropic gelation method. The effects of different formulation parameters on the particle size, encapsulation efficiency and in vitro release profiles of the beads were investigated. Encapsulation efficiency of ketoprofen was higher (51-78 %) than that of propranolol HCl (12-29 %). Within 3 hours both drugs were totally released from the beads. Tablets were prepared by using pectin, pectin beads and zinc pectinate in order to achieve controlled release. By using zinc pectinate, the release of ketoprofen from the tablets could be controlled, about 60% of ketoprofen was released in 7 h.
Keywords :
PECTIN, IONOTROPIC GELATION, BEAD, TABLET, PROPRANOLOL HCL, KETOPROFEN