| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2011 , Vol 53 , Num 3
DEVELOPMENT AND VALIDATION OF A DISSOLUTION METHOD WITH UV ANALYSIS FOR COUMARIN TABLETS
Department of Pharmaceutical Technology, Anna University of Technology- Tiruchirappalli, Tiruchirappalli, Tamil Nadu India
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A dissolution test for coumarin tables was developed and validated. To establish a dissolution procedure various trials have been done in different pH and in stirring speeds and drug release was analyzed by previously validated UV spectrophotometric method. After selection of the best conditions, the method was validated using USP Apparatus II (paddle), 75-rpm rotation speed, 900 mL of phosphate buffer pH 6.8, and test time of 45 min. Previously the developed analytical method was validated for accuracy, precision and recovery studies. Statistical analysis proved that the method was precise, reproducible, selective, specific, and accurate for the analysis of coumarin.
Keywords :
COUMARIN, DISSOLUTION, TABLETS, VALIDATION, SPECTROPHOTOMETER