| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2011 , Vol 53 , Num 4
DEVELOPMENT AND EVALUATION OF FAST DISSOLVING TABLETS OF ONDANSETRON HCL USING VACUUM-DRYING APPROACH
CVM Institute for Degree Course in Pharmacy, New Vallabh Vidya Nagar, Anand, (Gujarat)
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The aim of present investigation was to design ’Traveler Friendly Drug Delivery System’ of Ondansetron HCl. Conventional tablet of Ondansetron HCl are not capable of rapid action and water is also needed. Tablets were formulated by direct compression using mannitol, superdisintegrants and camphor, whereby camphor, a subliming material, is removed by sublimation from compressed tablets. Tablets prepared with camphor (20%) and Ac-Di-Sol (6%) exhibited disintegration time (21 s) and friability (0.49%). Further to decrease the disintegration time and friability aerosol (0.5%) is used as lubricant, which gives least disintegration time (19 s) and friability (0.32 %).
Keywords :
VACUUM-DRYING TECHNIQUE, CAMPHOR, MANNITOL, FAST DISSOLVING TABLET, AC-DI-SOL