| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2011 , Vol 53 , Num 4
FORMULATION AND EVALUATION OF GLICLAZIDE LOADED CONTROLLED RELEASE MICROSPHERES
Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India
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The aim of this study was to formulate and evaluation of gliclazide loaded controlled release microspheres. The microspheres were prepared by quasi emulsion solvent diffusion technique using Eudragit RLPO, Eudragit RSPO alone and with combinations. The effect of drug-polymer ratio and polymer-polymer ratio on percent yield, mean particle size, encapsulation efficiency and in vitro release were evaluated. In vivo test of the optimized formulation was performed on streptozotocin induced type-2 diabetic rat model. The formulated microspheres showed higher encapsulation efficiencies. The in vivo study revealed that the hypoglycemic effect obtained by microspheres was more than 25 h suggesting microspheres are a valuable system for sustained delivery of gliclazide.
Keywords :
MICROSPHERES, EUDRAGIT RSPO, QUASI EMULSION SOLVENT DIFFUSION, HYPOGLYCEMIA