| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2011 , Vol 53 , Num 4
SODIUM ALGINATE BASED IN-SITU GELLING SYSTEM OF KETOROLAC TROMETHAMINE: FORMULATION, EVALUATION AND OPTIMIZATION USING 2D CONTOUR PLOT
Department of Pharmaceutical Science, Jaipur National University, Jaipur, India
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The present investigation concerns with the development and optimization of pH specific sodium alginate based in-situ gelling system containing ketorolac tromethamine. The experiments were designed using 32 full factorial designs with an objective to retain in stomach for an extended time period. Based on preliminary trial, the concentration of sodium alginate (X1) and calcium carbonate (X2) were selected as formulation variables. The effect of selected independent factor on response variables such as percentage drug release at 1h (Q1), time required to release 80% of drug (t80%) and viscosity, were studied from the two dimension (2D) contour plot. Results of analysis of variance conformed that both formulation variable had a significant effect on studied response, as p- value less than 0.05. The validation of proposed model were performed by designing two check point formulation (A1, A2) based on the visual inspection of 2D contour plot of studied response. The comparison of observed and predicted response of A1 and A2 showed good similarity in response variable. Results of accelerated stability study showed no significant change in response variables. Hence, it was concluded that controlled release of ketorolac tromethamine can be achieved by sodium alginate based in-situ gelling system.
Keywords :
IN-SITU GEL, KETOROLAC TROMETHAMINE, CHECK POINT, COUNTER PLOT