ACTA Pharmaceutica Sciencia 2011 , Vol 53 , Num 1
FABRICATION AND IN VITRO EVALUATION OF GLIQUIDONE MATRIX TABLETS WITH ABELMOSCHUS ESCULENTUS FRUIT MUCILAGE AND POVIDONE COMBINATION
HİNDUSTAN ABDUL AHAD, SREENİVASULU RAVOORİ, KİSHORE KUMAR REDDY BUDİDETİ, SRAVANTHİ MORE, SİDDAİAH GUDDETİ, VAMSİ KRİSHNA REDDY PATİL
College of Pharmacy, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, India The main objective of the present study was to develop matrix tablets of Gliquidone with Abelmoschus esculentus fruit mucilage and Povidone and to study its functionality as a matrix forming agent for controlled release tablet formulations. Physicochemical properties of dried powdered mucilage of A. esculentus mucilage were studied. Various formulations containing Gliquidone, A. esculentus fruit mucilage and Povidone were prepared. The drug-excipient compatibility studies, physicochemical properties, pre compression and post compression properties were performed and satisfactory results were obtained. These results proved that the dried A. esculentus mucilage and Povidone combination can be used as a matrix forming material for making controlled release matrix tablets. Keywords : GLIQUIDONE, ABELMOSCHUS ESCULENTUS, POVIDONE, MATRIX TABLETS, CONTROLLED RELEASE

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