| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2011 , Vol 53 , Num 2
DESIGN, DEVELOPMENT, AND OPTIMIZATION OF MOUTH DISSOLVING TABLETS OF LEVOCETIRIZINE DIHYDROCHLORIDE USING CENTRAL COMPOSITE DESIGN
Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Indi
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The aim of the present research work was to design and develop an optimized mouth dissolving tablet dosage form of an anti-allergic drug, Levocetirizine dihydrochloride. Independent variables such as the amount of subliming agent-camphor (X1) and the amount of superdisintegrant-crospovidone (X2) were optimized using a 2-factor, 3-level Central Composite Design. The dependent variables selected were the disintegration time, wetting time, cumulative % drug release in 10 min. and water absorption ratio of the tablet. The mathematical relationships were generated using multiple linear regression analysis and all the polynomial equations were found to be statistically significant (P<0.0002), as determined using ANOVA.
Keywords :
MOUTH DISSOLVING TABLETS, LEVOCETIRIZINE DIHYDROCHLORIDE, SUPERDISINTEGRANT, SUBLIMING AGENT, CENTRAL COMPOSITE DESIGN