| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2006 , Vol 48 , Num 3
DETERMINATION OF ENALAPRIL MALEATE IN PHARMACEUTICAL PREPARATIONS USING METHYL ORANGE
Istanbul University, Faculty of Pharmacy, Department of Analytical Chemistry, Beyazıt-Istanbul-Turkey
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A simple and sensitive spectrophotometric method has been developed for the determination of enalapril maleate in pharmaceutical preparations. This method is based on the formation of a yellow colored ion-pair complex by the reaction of methyl orange with enalapril maleate in acidic (pH 3.5) medium. Under optimised conditions, they showed absorption maxima at 425 nm. Linear relationship was obtained over the enalapril maleate concentration ranges of 4.0-20 μg/mL. The detection and quantification limits of enalapril maleate were 1.32 and 4.0 μg/mL, respectively. The proposed method is suitable for the routine analysis and quality control of enalapril maleate in pharmaceutical preparations.
Keywords :
ENALAPRIL MALEATE, METHYL ORANGE, EXTRACTION SPECTROPHOTOMETRY, ION-PAIR COMPLEX, PHARMACEUTICAL PREPARATIONS