| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2011 , Vol 53 , Num 4
SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEMS (SMEDDS) OF EFAVIRENZ: FORMULATION DESIGN, IN VITRO AND IN VIVO ASSESSMENT
S.K. Patel College of Pharmaceutical Education and Research, Ganpat University, Gujarat, India
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Efavirenz SMEDDS formulations containing lipid, surfactant and cosurfactant were developed and evaluated in vitro and in vivo. Pseudo-ternary phase diagrams composed of lipid, cosurfactant, surfactant and water were mapped and the region of microemulsion occurring was plotted. SMEDDS formulations were investigated for microemulsifying properties, clarity, precipitation, % Transmittance, Viscosity, Droplet size/size distribution, Zeta potential and long-term physical stability. The morphology of efavirenz microemulsion was observed by transmission electron microscopy (TEM). The in vitro release profiles of SMEDDS were compared with the release profiles of efavirenz from the conventional tablet and pure efavirenz. The pharmacokinetic study was performed by oral administration of 4.465 mg/kg efavirenz to Albino rats in different formulations. The oral bioavailability of efavirenz in SMEDDS capsules was significantly increased than that of the conventional tablet (p<0.05). The study confirmed that SMEDDS formulation can be used as a possible alternative to traditional oral formulations of efavirenz to improve its bioavailability.
Keywords :
EFAVIRENZ, SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEMS, BIOAVAILABILITY, PSEUDO TERNARY PHASE DIAGRAM, DISSOLUTION