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ACTA Pharmaceutica Sciencia
2010 , Vol 52 , Num 1
TRANSNITROSATION REACTION BETWEEN CAPTOPRIL AND SODIUM NITROPRUSSIDE
Chitkara College of Pharmacy, Rajpura, Dist. Patiala, India
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In this method transfer of nitric oxide from Sodium nitroprusside to Captopril has been observed by using UV-visible spectrometric measurements in tris buffer at various pH such as pH=6, pH=7.4 and pH=9. Reaction was studied at various conditions for instance with stirring at room temperature or constant heating with stirring and continuous stirring at different temperatures in various buffer. The reaction was completed in 6 days at pH 7.4, 2 days at pH 6 and 3 days at pH 9.
Keywords :
NITRIC OXIDE (NO), SODIUMNITROPRUSSIDE (SNP), TRIS BUFFER