| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2010 , Vol 52 , Num 1
DEVELOPMENT OF FLOATING MICROSPHERES TO IMPROVE ORAL BIOAVALIBITY OF CEFPODOXIME PROXETIL
Department of Pharmaceutics, Nehru College Pharmacy, Pambady, Thiruvilwamala, Thrissur dist., Kerala State-India
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The objective of the present study was to develop floating microspheres of Cefpodoxime Proxetil (CP) in order to achieve an extended retention in the upper GIT, to protect the prodrug from enzymatic attack which may enhance the absorption and improve the bioavailability. The microspheres were prepared by non aqueous solvent evaporation method using different ratios of Cefpodoxime Proxetil, hydroxyl propyl methyl cellulose (HPMC K4M) and ethyl cellulose (1:1:1, 1:1:2,1:1:3,1:1:4,1:1:5 and 1:1:6), in the mixture dichloromethane and ethanol at ratio of (1:1), with tween80 as the surfactant. The floating microspheres were characterized by and results obtained are Particle size analysis (75-600 μm), buoyancy percentage (68.2-88.45), drug entrapment efficiency (27.5%-48.5%), % yield (50.5-70.1) and in vitro drug release was studied for 12 h. The floating microspheres showed better result and it may be use full for prolong the drug release in stomach and improve the bioavailability.
Keywords :
FLOATING MICROSPHERES, CEFPODOXIME PROXETIL, HYDROXYL PROPYL METHYL CELLULOSE, ETHYL CELLULOSE, IN VITRO RELEASE STUDIES, BIOAVAILABILITY