| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2007 , Vol 49 , Num 3
FORMULATION AND IN VITRO EVALUATION OF SUSTAINED RELEASE DOSAGE FORM OF ACETAZOLAMIDE
Department of Pharmacy, Annamalai University, Annamalainagar – Chidambaram (Tamil Nadu), INDIA
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Acetazolamide sustained release (S.R.) capsule 500 mg was prepared according to release pattern suggested by Wagner (1971). Comparative release pattern of the drug from S.R. pellets by using glyceryl monostearate, microcrystalline wax and microcrystalline wax and glyceryl distearate was studied. 00 hard gelatin capsule filled with combination of 35% of drug coated pellets (DC) and 65% of DC with 1:1 ratio of microcrystalline wax and glyceryl distearate on basis of drug content was successful and found stable in evaluations. Application of various kinetic equations to in vitro data indicated biphasic zero order release.
Keywords :
ACETAZOLAMIDE 500 MG, SUSTAINED RELEASE, CAPSULE, IN VITRO