| Acceptance rate | 46% |
|---|---|
| Time to first decision | 6 months* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2007 , Vol 49 , Num 2
PROSTAGLANDIN MEDIATED ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF CISSAMPELOS PAREIRA
Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Lucknow-Uttar Pradesh, India
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50% ethanolic extract of the aerial part of Cissampelos pareira Linn. var. Hirsuta (Menispermaceae) was tested for anti-inflammatory (paw edema induced by carrageenin and arachidonic acid) and analgesic activity (abdominal writhes and hot plate) in rats and mice, respectively. Oral administration of extract exhibited significant and dose dependent anti-inflammatory activity in the carrageenin test, which was based on interference with prostaglandin synthesis, as confirmed by the arachidonic acid test. In the abdominal writhing test induced by acetic acid, higher dose of the plant extract had the highest analgesic activity, whereas in the hot-plate test the best dose was 100 mg/kg (P < 0.05). The LD50 showed that Cissampelos pareira (2000 mg/kg) presented low toxicity.
Keywords :
CISSAMPELOS PAREIRA, ANTI-INFLAMMATORY, ANALGESIC, PROSTAGLANDIN