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ACTA Pharmaceutica Sciencia
2007 , Vol 49 , Num 1
CHEMOMODULATORY INFLUENCE OF CISSAMPELOS PAREIRA (L.) HIRSUTA ON GASTRIC CANCER AND ANTIOXIDANT SYSTEM IN EXPERIMENTAL ANIMAL
Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, (Council of Scientific and Industrial Research) Rana Pratap Marg, Uttar Pradesh, India
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The objective of the present study was to investigate the protective effect of ethanolic extract of Cissampelos pareira (CPE) against gastric cancer and its mode of action. The bioassay-guided fractionation of the CPE yielded a compound, identified as 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one (Quercetin) with the help of NMR and various spectrophotometer methods as U.V., I.R. and other chemical tests. The protective effects of C. pareira were studied against Benzo(a)pyrene (B(a)P) induced gastric cancer, tumor multiplicity, micronucleus polychromatic erythrocytes (MnPCEs) in mice. The effect of CPE on SOD, CAT, LPO and GST, GPx, GSH was also studied.
Keywords :
CISSAMPELOS PAREIRA, QUERCETIN, GASTRIC CANCER, MICRONUCLEUS POLYCHROMATIC ERYTHROCYTES