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ACTA Pharmaceutica Sciencia 2026 , Vol 64 , Num 2
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Exploring the abundance of de-oiled non-resin analgesic and anti-inflammatory compounds in Crocus sativus through polarity-directed quaternary solvent extraction in both diabetic and non-diabetic conditions: Integrating in silico and in vivo analysis
Sheikh Rakibul ALAM 1 Najibah NASRIN 2 Nargis Sultana CHOWDHURY 3 Romana AKTER 4 Md Abdur RAHMAN 3 Rifah Noor CHOWDHURY 5 Md Rafat TAHSIN 6 Tasniv Ahsan ARNOB 6 Niaz MORSHED 7 Md Sajjad Hossain MIA 8 F. A. Dain Md OPO 8 Fahima AKTAR 7 Md Mahfuz MIAH 9 Sultan Mehtap BÜYÜKER 10 Rumman REZA 7 Muhammad Salehuddin AYUBEE 11 Md Selim REZA 12 Jakir Ahmed CHOWDHURY 12 Abu Asad CHOWDHURY 7 Shaila KABIR 7 Md Shah AMRAN 13
1 Dhaka Dental College, Dhaka, Bangladesh
2 Daffodil International University, Faculty of Health and Life Sciences, Birulia, Savar, Dhaka-1216, Bangladesh
3 Manarat International University, Department of Pharmacy, Dhaka, Bangladesh
4 University of Dhaka, Department of Biochemistry and Molecular Biology
5 University of Dhaka, Faculty of Pharmacy, Department of Clinical Pharmacy and Pharmacology, Dhaka-1000, Bangladesh
6 North South University, Department of Pharmaceutical Sciences, Bangladesh
7 University of Dhaka, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Molecular Pharmacology and Herbal Drug Research Laboratory, Bangladesh
8 University of Asia Pacific, Department of Pharmacy, Farmgate, Dhaka, Bangladesh
9 Southeast University, Department of Pharmacy, Bangladesh
10 Istanbul Medipol University, School of Pharmacy, Department of Pharmaceutical Toxicology, Istanbul, Türkiye
11 Northern University Bangladesh, Faculty of Health Science, Department of Pharmacy, Bangladesh
12 University of Dhaka, Faculty of Pharmacy, Department of Pharmaceutical Technology, Bangladesh
13 Independent University, School of Pharmacy and Public Health, Department of Pharmacy, Bangladesh
DOI : 10.23893/1307-2080.APS64012 Viewed : 21 - Downloaded : 3 Prior research indicated that the whole extract of Crocus sativus exhibited substantial analgesic and anti-inflammatory effects at a dose of 400 mg/kg. We aimed to examine the anti-inflammatory and analgesic activities of a de-oiled, non-resin fraction of C. sativus petals. The 20% n-hexane, 60% ethanol, 20% water extract of de-oiled, non-resin fraction of C. sativus was administered at 100, 200, and 400 mg/kg in rats. Study was conducted in both diabetic and non-diabetic models. The de-oiled, non-resin fraction of C. sativus petal extract imparts significant (p<0.05) anti-inflammatory and analgesic activity at a 200 mg /kg dose, both in diabetic and non-diabetic rats. So, the extract may also contain anti-diabetic compound to ameliorate diabetic condition to demonstrated identical impact both in diabetic and non-diabetic condition. It may be stated that the de-oiled, non-resin fraction of C. sativus is a potent source of analgesic and anti-inflammatory compounds in diabetic and nondiabetic conditions. Keywords : Crocus sativus, petal, analgesic, anti-inflammatory, histopathology

Istanbul Medipol University