| Acceptance rate | 46% |
|---|---|
| Time to first decision | 20 days* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2024 , Vol 62 , Num 2
Effects of tadalafil on vancomycin-induced nephrotoxicity in rats
1 Medico-legal Directorate, MOH, Laboratories Department, Baghdad, Iraq2 Department of Pharmacology, College of Medicine, University of Warith Al-Anbiyaa, Karbala, Iraq
DOI : 10.23893/1307-2080.APS6220 Tadalafil (TAD) is a member of the Phosphodiesterase 5 (PDE 5) inhibitors used to treat erectile dysfunction. However, recent evidence suggests that it has beneficial nephroprotective effects via a variety of mechanisms. The aim of the present study was to investigate the protective effect of TAD against vancomycin (VAN) - induced nephrotoxicity in rats (n=24), which divided into three groups; model control group that received intraperitoneal VAN, TAD group that received oral TAD and intraperitoneal VAN and normal healthy group. TAD group demonstrated a significant decrease in serum levels of renal function biomarkers and a significant increase in creatinine clearance level compared to the model control group. Furthermore, it showed a significant reduction in the renal levels of malondialdehyde (MDA), neutrophil gelatinase-associated lipocalin (NGAL), and TNF-? with a significant elevation in the renal level of glutathione (GSH) compared to the model control group. Histologically, TAD group showed a significant reduction in renal tissue injury that prove its nephroprotective effect due to its antioxidant and anti-inflammatory properties. Keywords : oxidative stress, nephrotoxicity, tadalafil, vancomycin