Acceptance rate 46%
Time to first decision 20 days*
Time to decision with review 50 days*

*Approximate number of days

**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.


ACTA Pharmaceutica Sciencia 2011 , Vol 53 , Num 1
COMPARATIVE EVALUATION OF NATURAL AND SYNTHETIC SUPERDISINTEGRANTS WITH NEWER SUPERDISINTEGRANT KYRON T-314
GATTU JYOTHİ, P K LAKSHMİ
G.Pulla Reddy College of Pharmacy, Mehidipatnam, Hyderabad, Andhra Pradesh, India The main objective of this study was to formulate and evaluate the orodispersible tablets of ondansetron hydrochloride with synthetic and natural superdisintegrants. Various formulations were prepared by direct compression using different concentrations of natural superdisintegrant i.e. isolated mucilage of Plantago ovata and synthetic superdisintegrants namely Kyron T-314, crospovidone, and croscarmellose sodium ranging from 0.4% to 2%. The initial compatibility studies between the drug and excipients were carried out using FTIR spectroscopy. The blend was evaluated for additive properties. The tablets were evaluated for physical parameters and in vitro drug release. The disintegration time and in vitro drug release of optimized formulation (FK5) was compared with that of marketed formulation. The disintegration time was found to be 32 sec as compared to 49 sec for marketed formulation. The dissimilarity (f1) and similarity factors (f2) were calculated for optimized and marketed formulation and values were found to be 9.63 and 52.46, respectively. The optimized formulation was subjected to stability studies for three months. The formulation was found to be stable, with insignificant change in the hardness, disintegration time, drug content and in vitro drug release pattern. Keywords : ORODISPERSIBLE TABLET, ONDANSETRON HYDROCHLORIDE, KYRON T-314, CROSPOVIDONE, CROSCARMELLOSE SODIUM, ISOLATED MUCILAGE OF PLANTAGO OVATA

Istanbul Medipol University