ACTA Pharmaceutica Sciencia 2020 , Vol 58 , Num 3
Effect of Salvia Officinalis on Neuromodulating and Oxidative Stress Status in Brain of Male Albino Wistar Rats Intoxicated with Aluminium
Nishat Fatima 1 Afreen Tabassum 1
1 Department of Pharmacology, Shadan Women?s College of Pharmacy, Khairtabad, Hyderabad
DOI : 10.23893/1307-2080.APS.05816 The present study reflects the effect of plant extracts of Salvia officinalison neuromodulating and oxidative stress status of Male Albino Wistar rats intoxicated with Aluminium chloride.

Rats were divided into7 groups of 6 in each. Apart from normal control, toxicant and standard, rats also received 250mg/kg and 500mg/kg doses of aqueous and ethanolic extracts of Salvia officinalis for20 days. Behavioral parameters, along with acetylcholinesterase enzyme levels, antioxidant markers and histopathology of brain tissues were determined.

Salvia officinalis improved behavioral parameters and reversed the reduced Acetylcholinesterase content thereby increased SOD and decreased MDA and NO when compared to AlCl3 induced rats.

The study demonstrated the beneficial effects of Salvia officinalis in Alzheimer"s disease by showing antioxidant, AchE inhibiting activity and by improving memory and cognitive functions. Keywords : Alzheimer"s disease, Aluminium chloride, Acetylcholinesterase, Salvia officinalis

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