ACTA Pharmaceutica Sciencia 2019 , Vol 57 , Num 4
Formulation and Evaluation of Topical Gel Containing Nanostructured Lipid Carriers Dispersion of an Antifungal Drug
Srinivas Gujjar 1 Madhavi BLR 1 Roopa Karki 1
1 Department of Pharmaceutics and Industrial Pharmacy, Acharya & BM Reddy College of Pharmacy, 5 Soldevanahalli, Bengaluru, Karnataka 560107
DOI : 10.23893/1307-2080.APS.05724 Fungal infection are the common dermatological diseases. Drug delivery systems for topical use have shown significant advantages in targeting the drug to the action site in the body and also reduces the systemic side effects.

In the present study an attempt was made to prepare econazole nitrate loaded nanostructured lipid carrier (NLC). Different formulations were prepared by hot homogenization technique using solid lipid and liquid lipid (GMS, GMO) and surfactants (Poloxamer 188, Poloxamer 407). Formulations were characterized for entrapment efficiency, viscosity, spreadability, pH and in vitro drug release.

Entrapment efficiency of formulation F1-F8 was found to be 65.81-74.63%. The drug release of NLC gel followed zero order kinetics. NLC gel were stable at 40 ± 2°?C and 75 ± 5% RH. Thus, the prepared NLC gel proved to be a potential candidate as a topical nanoparticulate sustained drug delivery system for econazole nitrate. Keywords : Nanostructured lipid carrier, Econazole nitrate, Glyceryl monostearate, Glyceryl monooleate, hot homogenization

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