ACTA Pharmaceutica Sciencia 2008 , Vol 50 , Num 3
COMPARATIVE STUDIES ON DICLOFENAC SODIUM LOADED ALBUMIN/GELATIN MAGNETIC MICROSPHERES FOR INTRA-ARTERIAL ADMINISTRATION
M SARAVANAN, V AKHILESH VIJAY, PRADEEP KUMAR, A SUSHMA, S PRIYA, G MAHARAJAN, K SADASIVAN PILLAI, S PANDEY
School of Pharmacy, Faculty of Medical Sciences, University of West Indies, Trinidad Magnetite was prepared by oxidation of ferrous sulphate by sodium hydroxide. Diclofenac sodium loaded gelatin and albumin magnetic microspheres were prepared by emulsification/cross-linking by glutaraldehyde using ethylcellulose in chloroform and sesame oil with/without span80 as stabilizing medium. The microspheres were characterized by drug loading, entrapment/encapsulation efficiency, particle size, optical microscopy, magnetite content and in vitro release studies. Sesame oil with span80 was found to yield spherical and compact microspheres. Gelatin magnetic microspheres showed better loading, entrapment, encapsulation, release profile and stability than albumin magnetic microspheres. Keywords : GELATIN, ALBUMIN, MAGNETIC MICROSPHERES, MAGNETITE, DICLOFENAC SODIUM

Istanbul Medipol University