ACTA Pharmaceutica Sciencia 2004 , Vol 46 , Num 2
COMPARATIVE EFFICACY OF FOUR HERBAL ANTIDIABETIC FORMULATIONS IN ALBINO RABBITS
M RAFEEUDDİN, J BHEEMACHARİ, N VENKAT RAO, S RAMACHANDRA SETTY
Dept of Pharmacology; V. L. College of Pharmacy, Raichur - , Kamataka, India A number of herbal formulations are marketed globally, claiming to be useful in diabetes and other associated diseases such as atherosclerosis. In the present study an attempt has been made to study the comparative efficacy of four such marketed herbal oraI antidiabetic formulations, for their hypoglycemic and hypolipidemic activities. The study was conducted on healthy albino rabbits of either sex, randomly distributed into control and test groups. The hypoglycemic activity was studied by measuring the reduction in blood glucose levels at different time intervals using GOD/POD method. The hypolipidemic activity was performed by routine techniques. The fonnulations tested were compared for their hypoglycemic and hypolipidemic activities for efficacy ranging. The formulations which exhibited significant hypoglycemic activity were then compared with tolbutamide. The results demonstrated a moderate to considerable difference in the hypolipidemic and hypoglycemic activities among the products tested. The present stud¥ provides a ready reference to health care practitioners for the appropriate selection of the herbal formulation in clinical practice. Keywords : HERBAL FORMULATIONS, HYPOGLYCEMIC ACTIVITY, HYPOLIPIDEMIC ACTIVITY, ALTERNATIVE SYSTEM

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