ACTA Pharmaceutica Sciencia 2010 , Vol 52 , Num 2
SYNTHESIS OF PALMITIC ACID DERIVATIVES OF P-AMINOPHENOL AND P-AMINO BENZOIC ACID WITH IMPROVED PHARMACODYNAMIC PROFILES
ASMA SAQİB, MOHAMMED AFZAL PASHA, CHANDRAKANT KARİGAR, METTİCULE SHANKAR NARAYANA RAO HARİSH
Department of Biochemistry, Central College Campus, Bangalore University, Bangalore, India In the present study, p-amino phenol (PAP) and p-amino benzoic acid (PABA) have been modified as lipids palmitoyl p-amino phenol (PPAP) and palmitoyl N - p-amino benzoic acid (N-PPABA) by a simple amide formation reaction of the respective compounds with palmitoyl chloride. On screening PPAP and N-PPABA for pharmacological activity, PPAP (an analogue of paracetamol) has been found to exhibit potent and persistent analgesic and inflammatory activity than paracetamol. Whereas N-PPABA, an amide of p-amino benzoic acid demonstrated novel analgesic, antiinflammatory and antipyretic effects. Keywords : PARACETAMOL, PPAP, N-PPABA, CYCLOOXYGENASE, ANTINONICEPTIVE, NSAID‘S

Istanbul Medipol University