| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2025 , Vol 63 , Num 3
Antibacterial activity and UPLC analysis of Hypericum perforatum L. extracts
1 Istanbul Medipol University, Institute of Health Sciences, Istanbul, Türkiye2 Istanbul Medipol University, School of Medicine, Department of Medical Pharmacology, Istanbul, Türkiye
3 University of East London, School of Health, Sport and Bioscience, Department of Bioscience, Medicines Research Group, London, UK, United Kingdom
DOI : 10.23893/1307-2080.APS6334 Viewed : 2563 - Downloaded : 1146 Hypericum perforatum L. has been used for centuries as a herbal remedy against variety of diseases for its biological activities. It has been also used as an antibacterial agent against different bacteria. The aim of this study is to investigate the antibacterial properties of the H. perforatum L. extracts against several clinical isolates and explore their chemical composition. In terms of S. aureus strains, n-hexane extract demonstrated the best activity against XU212 strain, with the MIC of 256 µL/mL. The MIC was 512 µL/mL for other S. aureus strains for n-hexane and dichloromethane extracts. n-hexane extract demonstrated activity against E. coli ATCC 25922 with the MIC of 1 µL/mL. UPLC was performed for dichloromethane and methanol extracts. The main compounds were identified as catechin, hyperforin, and rutin from methanol extract, and hypericin and luteoskyrin from dichloromethane extract. S. aureus demonstrated good antibacterial activity against tested MRSA and Bacillus subtilis strains. Keywords : Hypericum perforatum L., extract, antibacterial activity, MRSA, UPLC