| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2024 , Vol 62 , Num 4
Study the effect of thyroid disorder on Paraoxygenase -1, Malondialdehyde (MDA) and reduced Glutathione (GSH) in a sample of Iraqi patients
1 Mustansiriyah University, College of Science, Chemistry Department, Baghdad, Iraq2 Mustansiriyah University, College of Science, Biology Department, College of Science, Baghdad, Iraq
DOI : 10.23893/1307-2080.APS6253 Viewed : 3548 - Downloaded : 1326 Paraoxonase-1 (PON-1), it is an antioxidant enzyme that associate with highdensity lipoproteins, plays a crucial role in mitigating lipid peroxidation. Three paraoxonase forms (PON-1, 2, and 3), with PON-1 synthesized in the liver and transported with HDLs in the plasma. This study aimed to estimate the levels of paraoxonase-1, malondialdehyde (MDA), and reduced glutathione (GSH) in the sera of patients with thyroid dysfunction that include 50 patients; 25 with hypothyroidism and 25 with hyperthyroidism which compared with 25 healthy controls in a study conducted between May and July 2023, utilized the enzymelinked immunosorbent assay (ELISA) for PON-1, the thiobarbituric acid (TBA) method for MDA, and Ellman"s method for GSH which revealed that there is a significant reduction in PON-1 activity and GHS levels in both hypothyroid and hyperthyroid groups compared to controls, with a significant increase in MDA levels in the hyperthyroid and hypothyroidism groups which indicates that thyroid dysfunction influences oxidative stress markers (MDA and GSH) and PON-1 activity, which can be used as a potential biomarker for early diagnosis or as a therapeutic target for monitoring thyroid dysfunction"s clinical status. Keywords : paraoxonase-1, malondialdehyde, lipid peroxidation, glutathione, thyroid