ACTA Pharmaceutica Sciencia 2023 , Vol 61 , Num 1
Biological activity and chemical composition of the essential oil from the fruits of Ferula halophila Peşmen
Mine KÜRKÇÜOĞLU 1 Gökalp İŞCAN 1 Fatma TOSUN 2 Mahmut MİSKİ 3
1 Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Eskisehir, Türkiye
2 Department of Pharmacognosy, School of Pharmacy, Istanbul Medipol University, Istanbul, Türkiye
3 Department of Pharmacognosy, Faculty of Pharmacy, Istanbul University, Istanbul, Türkiye
DOI : 10.23893/1307-2080.APS6106 The hydrodistilled essential oils of the dried fruits of F. halophila Peşmen, an endemic species growing near Salt Lake in Central Anatolia, were analyzed by GC and GC-MS systems; 27 and 24 compounds representing 92.1% and 79.8% of the essential oils were characterized, respectively. The main component of the essential oils was identified as ?-phellandrene. The antibacterial and anticandidal effects of the essential oils were determined by using partly modified CLSI methods M7-A7 and M27-A2, respectively. The essential oils from two specimens showed weak to moderate inhibitory effects on the tested pathogenic bacteria (MIC, 125-2000 µg/ mL) and Candida panels (MIC, 156-1250 µg/mL). Keywords : Antibacterial, anticandidal, essential oil, Ferula halophila

Istanbul Medipol University