| Acceptance rate | 46% |
|---|---|
| Time to first decision | 20 days* |
| Time to decision with review | 50 days* |
*Approximate number of days
**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.
ACTA Pharmaceutica Sciencia
2022 , Vol 60 , Num 1
In vivo inhibitory effect of hydro-ethanol extract of Xylopia aethiopica fruits on mediators of acute inflammation
1 Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, GhanaDOI : 10.23893/1307-2080.APS.6006 Xylopia aethiopica is traditionally employed, as fruit decoction, in the management of bronchitis, asthma and arthritis in Ghana. This study is to evaluate the involvement of the hydro-ethanol extract of the dried fruit of X. aethiopica on some inflammation pathways by employing in vivo murine models. X. aethiopica (30, 100, 300 mg kg-1) suppressed the mean maximal swelling attained at 60-90 min and also decreased the total paw swelling induced over 2.5-3 h significantly (p < 0.05). The extract suppressed mean maximal swelling attained at 60-90 min in the respective histamine, serotonin, bradykinin and prostaglandin E2-induced oedema models when compared with their respective mean inflamed control responses. Total paw swellings induced over the 2.5-3 h were also significantly suppressed in all mediator-challenged mice. The current study establishes that X. aethiopica extract has inhibitory effect on histamine, serotonin, bradykinin and prostaglandin E2 in acute inflammation. Keywords : Acute inflammation, anti-inflammatory, oedema, Xylopia aethiopica extract