| Submission to first decision
(The average time from manuscript submission to desk rejection, direct rejection/acceptance or assignment to the first editor) Note: For manuscripts that fully comply with the journal template. However, this timeframe does not apply to manuscripts with formatting or guideline deficiencies. If a manuscript is returned to the authors for corrections, the administrative review process will restart from the re-submission date. |
3 weeks |
|---|---|
| Submission to decision after review (For papers that are sent to review, the average time from submission to receipt of first editor decision) | 6 weeks |
| Submission to final decision (The average time from manuscript submission to the final editorial decision) | 16 weeks |
| Submission to publication (The average time from acceptance to publication. Manuscript published in early view are also included in this calculation) | 24 weeks |
ACTA Pharmaceutica Sciencia
2019 , Vol 57 , Num 2
Preparation and In vitro Characterization of a Fluconazole Loaded Chitosan Particulate System
1 Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 26470 Eskişehir, TürkiyeDOI : 10.23893/1307-2080.APS.05713 Viewed : 18482 - Downloaded : 5508 ABSTRACT In the present study fluconazole (FZ) was successfully incorporated into cationic chitosan nanoparticles prepared by spray-drying method aiming dermal delivery. Particle size and zeta potential measurements, drug content, morphological, thermal and XRD analyses and FZ quantification by HPLC analyses were performed for characterizing the formulations prepared. Release behavior of FZ from the nanoparticles was determined using a Franz-diffusion cell. Thermal and XRD analyses results indicated that FZ was molecularly dispersed in chitosan nanoparticles. Cationic chitosan nanoparticles released FZ for 180 minutes indicative of the extended release of the drug. In vitro characterization results demonstrated that chitosan nanoparticles seem to be promising for enhancement of dermal delivery of FZ and could decrease potential side effects and reduce the potential of drug resistance. Keywords : Fluconazole, Chitosan, Nanoparticles, Spray-drying, Franz-diffusion cell