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ACTA Pharmaceutica Sciencia
2008 , Vol 50 , Num 3
COMPARISON OF THE EFFECT OF ESSENTIAL OILS ON THE PERMEATION OF DICLOFENAC DIETHYLAMINE THROUGH VARIOUS BARRIERS
Department of Pharmaceutics, N.E.T Pharmacy College, Manthralayam road, Raichur.India
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Ethylcellulose transdermal patches for diclofenac diethylamine (DDA) using essential oils as penetration enhancers developed. Effect of drug loading and penetration enhancers on the in vitro permeation of drug through cellophane membrane, rat skin and human cadaver skin was investigated. Incorporation of essential oils enhanced the moisture content, moisture uptake capacity and permeation of diclofenac diethylamine across skin barriers. Among the penetration enhancers used, menthol oil found to be most effective. Comparison of steady state flux (J) values obtained with various barriers revealed that permeation was in following order: rat skin cellophane membrane human cadaver skin. Stability studies did not show any degradation of the drug. In conclusion, stable and effective diclofenac diethylamine transdermal patches can be prepared using essential oils as penetration enhancers.
Keywords :
TRANSDERMAL PATCHES; DICLOFENAC DIETHYLAMINE, ESSENTIAL OILS; PERMEATION STUDY