Acceptance rate 46%
Time to first decision 6 months*
Time to decision with review 50 days*

*Approximate number of days

**The days mentioned above are averages and do not indicate exact durations. The process may vary for each article.


ACTA Pharmaceutica Sciencia 2010 , Vol 52 , Num 2
SYNTHESIS OF PALMITIC ACID DERIVATIVES OF P-AMINOPHENOL AND P-AMINO BENZOIC ACID WITH IMPROVED PHARMACODYNAMIC PROFILES
ASMA SAQİB, MOHAMMED AFZAL PASHA, CHANDRAKANT KARİGAR, METTİCULE SHANKAR NARAYANA RAO HARİSH
Department of Biochemistry, Central College Campus, Bangalore University, Bangalore, India Viewed : 14933 - Downloaded : 4568 In the present study, p-amino phenol (PAP) and p-amino benzoic acid (PABA) have been modified as lipids palmitoyl p-amino phenol (PPAP) and palmitoyl N - p-amino benzoic acid (N-PPABA) by a simple amide formation reaction of the respective compounds with palmitoyl chloride. On screening PPAP and N-PPABA for pharmacological activity, PPAP (an analogue of paracetamol) has been found to exhibit potent and persistent analgesic and inflammatory activity than paracetamol. Whereas N-PPABA, an amide of p-amino benzoic acid demonstrated novel analgesic, antiinflammatory and antipyretic effects. Keywords : PARACETAMOL, PPAP, N-PPABA, CYCLOOXYGENASE, ANTINONICEPTIVE, NSAID‘S

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