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ACTA Pharmaceutica Sciencia
2010 , Vol 52 , Num 1
INVESTIGATING THE EFFECT OF VEHICLE ON IN VITRO SKIN PERMEATION OF KETOCONAZOLE APPLIED IN O/W MICROEMULSIONS
Indukaka Ipcowala College of Pharmacy, Sardar Patel University, New Vallabh Vidyanagar
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The purpose of this study was to investigate the effect of vehicle on in vitro skin permeation of ketoconazole applied in o/w microemulsions. The microemulsion formulation containing 2% ketoconazole was optimized with 14% isopropyl myristate, 42% tween 80/propylene glycol (5:1) and 42% double distilled water (w/w), which showed a highest permeation rate of 63.28 ± 4.93 μg cm-2 h-1. Candida Albicans was used as a model fungus to evaluate the antifungal activity of the best formula achieved. These results indicate that the studied microemulsion formulation might be a promising vehicle for future topical delivery of KTZ.
Keywords :
MICROEMULSION, KETOCONAZOLE, TOPICAL DELIVERY, IN VITRO SKIN PERMEATION STUDY ANTIFUNGAL ACTIVITY