ACTA Pharmaceutica Sciencia 2010 , Vol 52 , Num 1
INVESTIGATING THE EFFECT OF VEHICLE ON IN VITRO SKIN PERMEATION OF KETOCONAZOLE APPLIED IN O/W MICROEMULSIONS
MRUNALİ R PATEL, RASHMİN B PATEL, JOLLY R PARİKH, KASHYAP K BHATT, AJAY B SOLANKİ
Indukaka Ipcowala College of Pharmacy, Sardar Patel University, New Vallabh Vidyanagar The purpose of this study was to investigate the effect of vehicle on in vitro skin permeation of ketoconazole applied in o/w microemulsions. The microemulsion formulation containing 2% ketoconazole was optimized with 14% isopropyl myristate, 42% tween 80/propylene glycol (5:1) and 42% double distilled water (w/w), which showed a highest permeation rate of 63.28 ± 4.93 μg cm-2 h-1. Candida Albicans was used as a model fungus to evaluate the antifungal activity of the best formula achieved. These results indicate that the studied microemulsion formulation might be a promising vehicle for future topical delivery of KTZ. Keywords : MICROEMULSION, KETOCONAZOLE, TOPICAL DELIVERY, IN VITRO SKIN PERMEATION STUDY ANTIFUNGAL ACTIVITY

Istanbul Medipol University