ACTA Pharmaceutica Sciencia 2022 , Vol 60 , Num 2
Effect of oral use of various edible oils on wound healing in rats: randomized controlled experimental study
Gokce CAKMAK KAFADAR 1 Nihal BUYUKUSLU 2 Bircan KOLBASI 3 Ilknur KESKIN 4 Yeliz MERCAN 5
1 Faculty of Health Sciences Department of Nutrition and Dietetics, Kirklareli University, Kirklareli, Turkey
2 Health Sciences Institute Department of Nutrition and Dietetics, Istanbul Medipol University, Istanbul, Turkey
3 Faculty of Medicine Department of Histology and Embryology, Istanbul Medipol University, Istanbul, Turkey
4 Faculty of Medicine Department of Histology and Embryology, Istanbul Medipol University, Istanbul, Turkey
5 Health Sciences Institute Department of Public Health, Kirklareli University, Kirklareli, Turkey
DOI : 10.23893/1307-2080.APS.6013 There are various studies showing that oral supplements are shortening or facilitating effects on this process. Therefore, this study investigates the use of edible oils as supplements in the wound healing process. Of the 7 groups (control, Hypericum perforatum extracts in olive oil, olive, sesame, fish, black seed, sunflower), each has 8 Wistar Albino rats. In the experimental groups, 1.25 mL/kg oral oil was used for 10 days. Macroscopic images of the wound area were taken. Wound healing was evaluated by histological analysis. Collagen III, IL-6, TNF-? and TGF-ß1 density analyzes were performed on the tissue samples. According to macroscopic analysis, wound narrowing is higher in all groups on the 2nd and 4th days than the control group. Histopathological and immunohistochemical analyses of all experimental groups except sunflower oil group revealed better results than control group. Keywords : Hypericum perforatum olive oil extract, sesame oil, black cumin oil, olive oil, sunflower oil, wound healing

Istanbul Medipol University