ACTA Pharmaceutica Sciencia 2021 , Vol 59 , Num 1
Thiol Functionalization of Sesbania Gum and Its Evaluation for Mucoadhesive Sustained Drug Delivery
Shakuntla Verma 1 Munish Ahuja 1
1 Drug Delivery Research Laboratory, Department of Pharmceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar-125001(Haryana)
DOI : 10.23893/1307-2080.APS.05903 The objective of present study was to improve muco-adhesiveness of sesbania gum by thiol functionalization. Thiolated sesbania gum was synthesized by reacting sesbania gum with mercaptoacetic acid in the presence of catalytic amount of acids. The modified gum was characterized physic-chemically and for biocompatibility. Thiolated sesbania gum was tested as mucoadhesive polymer for pharmaceutical applications by formulating its composite beads in the sodium alginate using metformin as a model drug. Thiolation onto sesbania gum was confirmed by Fourier transform infrared spectroscopy and energy dispersive X-ray ?scanning electron micrographs. The degree of thiol substitution was found to be 1.72mmol/gm. The results of thrombogenic and haemolytic potential studies confirmed the biocompatibility of Thiolated sesbania gum. The comparative evaluation of composite beads of thiolated sesbania gum with sesbania gum and alginate alone beads revealed that thiolation of sesbania beads improves the bioadhesion property of sesbania gum. Keywords : Sesbania gum, thiolation, bead, biocompatible, mucoadhesive

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