ACTA Pharmaceutica Sciencia 2021 , Vol 59 , Num 1
Protective Effect of Exendin-4 Treatment On Oxidative Status Of Liver In Rats Exposed To Chronic Methylglyoxal
Esra Akcabağ 1 Selvinaz Dalaklıoğlu 1 İkbal Özen Küçükçetin 2 Sebahat Özdem 2 Arda Taşatargil 1 Sadi Satılmış Özdem 1
1 Akdeniz University, Medical Faculty, Department of Medical Pharmacology, 07070, Antalya, Turkey
2 Akdeniz University, Medical Faculty, Department of Medical Biochemistry, 07070, Antalya, Turkey
DOI : 10.23893/1307-2080.APS.05910 The protective effects of Glucagon-Like Peptide-1 (GLP-1) agonists against oxidative stress-induced cellular injury have been well established by previous experimental and clinical studies. Male Wistar rats (200-250 g weight, n=24) were used in this study. First group of rats were not treated with Methylglyoxal (MGO) and served as control group (C group). Second group of rats (MGO group) received MGO (75 mg/ kg/day in drinking water) for 12 weeks. Third group of rats (MGO+Ex-4) received Exendin-4 (Ex-4) (1 µg/kg twice daily subcutaneously) concomitant with MGO for 12 weeks. At the end of the 12th week, total oxidant status (TOS), total antioxidant capacity (TAC), sulfhydryl groups (SH), myeloperoxidase (MPO), and advanced oxidation protein products (AOPP) in the liver tissues of all groups were measured spectrophotometrically. In MGO-administered rats, TOS, MPO and AOPP levels were significantly increased. Treatment with Ex-4 for 12 weeks caused a significant decline in the levels of these markers in rats exposed to MGO. Also, levels of TAC and SH were decreased significantly after the 12 weeks of MGO administration. 12 weeks treatment with Ex-4 also increased the levels of TAC and SH in liver tissues of MGO-administered rats. Ex-4 treatment improves oxidative parameters of liver tissue in MGO-administered rats by improving oxidant-antioxidant balance. Keywords : Exendin-4, Methylglyoxal, Oxidative stress, Live

Istanbul Medipol University