ACTA Pharmaceutica Sciencia 2019 , Vol 57 , Num 1
Microbial Efficacy and Two Step Synthesis of Uridine Derivatives with Spectral Characterization
Sumi R. Devi 1 Sanjida Jesmin 1 Mahfuz Rahman 1 Mohammad A. Manchur 2 Yuki Fujii 3 Yasuhiro Ozeki 4 Sarkar M. A. Kawsar 1
1 Laboratory of Carbohydrate and Nucleoside Chemistry, Department of Chemistry, Faculty of Science, University of Chittagong, Chittagong 4331, Bangladesh
2 Department of Microbiology, Faculty of Biological Science, University of Chittagong, Chittagong-4331, Bangladesh
3 Department of Pharmacy, Faculty of Pharmaceutical Science, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo, Nagasaki 859-3298, Japan
4 Department of Life and Environmental System Science, Graduate School of NanoBio Sciences, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama 236-0027, Japan
DOI : 10.23893/1307-2080.APS.05704 Uridine is a natural nucleoside precursor of uridine monophosphate in organisms and thus is considered to be safe and is used in a wide range of clinical settings. The farreaching effects of pharmacological uridine have long been neglected. Here, we report a novel series of uridine esters were designed and synthesized by direct method with microbial efficacy. The structures of the prepared compounds have been characterized using various physico-chemical methods including C, H elemental analysis, melting point determination, IR and 1H-NMR spectroscopy. The synthesized uridine derivatives were subjected to in-vitro antibacterial screening using agar disc diffusion method on some clinically isolated Gram-positive and Gram-negative bacterial strains. Also, antifungal functionality test was performed against a number of plant pathogenic fungi. The compounds showed varied antibacterial and antifungal activities. In addition, cytotoxic activity showed different rate mortality with different concentrations. In conclusion, it may useful for antibacterial and antifungal active agents after investigating their further analysis to develop safer and more potent drugs in the future. Keywords : Synthesis, uridine, structure, efficacy, pathogens

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