ACTA Pharmaceutica Sciencia 2004 , Vol 46 , Num 2
ANTINOCICEPTIVE AND ANTI-INFLAMMATORY EFFECTS OF THE STANDARDIZED OIL OF INDIAN CALLISTEMON LANCEOLATUS LEAVES IN EXPERIMENTAL ANIMALS
M SUDHAKAR, V RAO, A LAKSHMAN RAO, D B RAJU
Shri Vishnu College of Pharmacy, Vishnupur, Bhimavaram A.P, India The effect of Callistemon lanceolatus (Family: Myrtaceae) leaf oil was studied for the anti nociceptive and anti-inflammatory activity in experimental animals. C lanceolatus, 25 - 100 mg/kg administered orally for 3 days exhibited graded dose response equivalent to 21.95% - 89.90% protection in the tail flick latent test in rat. The C. lanceolatus oil (50 and 100 mg/kg, p.o X 3 days) was effective in hot plate reaction time (64.05% and 112.97%, p< 0.01 and p< 0.001), analgesymeter induced mechanical pain (28.17% and 54.42%, p < 0.01 and p < 0.001) and acetic acid - induced writhing (26.68% and 51.79%, p < 0.5 and p < 0.05) in mice. The oil of C. lanceolatus potentiated the analgesic activity with pentazocine (to mg/kg, i.p.) and aspirin (25 mg/kg, Lp.). In the carrageenan- induced paw edema C. (anceolatus oil (50 and 100 mg/kg, p.o X 3 days) decreased paw volume significantly (26.68% and 51.79%) and dose dependent anti-inflammatory activity in 1-3 hour time interval and potentiated with nimesulide (50 mg/kg, p.o.). This study demonstrates that leaf oil of C. lanceolatus has significant anti nociceptive and anti-inflammatory activity. Keywords : CALLISTEMON LANCEOLATUS, VOLATILE OIL, PAIN, INFLAMMATION

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