ACTA Pharmaceutica Sciencia 2011 , Vol 53 , Num 2
SYNTHESIS, CHARACTERIZATION AND ANTINOCICEPTIVE ACTIVITY OF SOME 5- PHENYL -1-[5-(SUBSTITUTED PHENYL) ISOXAZOL-3-YL]-1H-TETRAZOLE
POPAT B MOHİTE, VAİDHUN H BHASKAR
Department of Pharmaceutical Chemistry, MES College of Pharmacy, Sonai, Ahmednagar, Maharashtra, India Nine different derivatives of 5-phenyl-1-(5-substituted phenyl isoxazol-3-yl)-1H-tetrazole (4a-i) were synthesized by reaction of chalcones with hydroxylamine hydrochloride in presence of aq. KOH. Compound (1) was cyclized using sodium azide and benzonitrile. The 5-phenyl tetrazoles on treatment with acetic anhydride forms 5-Phenyl 1-Acetyl Tetrazole (2) which on reaction with different aromatic aldehydes forms chalcones (3a-i). The chemical structures were confirmed by means of FT-IR, 1H-NMR and elemental analysis. The compounds were screened for antinociceptive activity by acetic acid induced writhing method and hot plate method. 5-phenyl-1-(5-phenyl isoxazol-3-yl)-1H-tetrazole (4a) was found to be the most active compound of the series. Keywords : TETRAZOLE, ISOXAZOLE, ANTINOCICEPTIVE ACTIVITY

Istanbul Medipol University