ACTA Pharmaceutica Sciencia 2021 , Vol 59 , Num 1
Formulation, Evaluation and Anti-Hemorroidal Activity of Suppositories Containing Moringa Oleifera Lam. Seed Oil
Christianah Y. Isimi 1 Lucy B. John-Africa 2 Kokonne E. Ekere 1 Olubunmi J. Olayemi 1 Olusola I. Aremu 3 Martins O. Emeje 1-4
1 Department of Pharmaceutical Technology and Raw Materials Development, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria
2 Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria
3 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, University of Ilorin, Nigeria
4 Centre for Nanomedicine and Biophysical Drug Delivery, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria
DOI : 10.23893/1307-2080.APS.05907 The plant Moringa oleifera has been reported to have various ethnomedicinal uses, of particular interest is the anti-inflammatory effect of the seed oil. In this study, suppository formulations containing Moringa seed oil (MSO) were developed for the management of inflammatory conditions of the anorectal region. The suppositories were prepared using a water soluble base, macrogol (MG) and a fatty base, dika fat (DF), obtained from Irvingia gabonensis seeds; they were evaluated for appearance, hardness, weight variation, melting point, pH, liquefaction time and in vitro release according to standard pharmacopoeia procedures. Anti-hemorroidal activity of the formulations in laboratory rats were also evaluated. Results show that all the suppositories prepared had good physicochemical properties. In vivo studies revealed that the optimized preparation containing dika fat was effective in reducing hemorrhoids induced in rats. Therefore, this study demonstrates the propensity of Moringa seed oil suppositories in the treatment of anorectal inflammatory conditions. Keywords : Moringa seed oil; suppositories; Dika fat; Macrogol; Anti-inflammatory

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