ACTA Pharmaceutica Sciencia 2020 , Vol 58 , Num 2
Quercetin Enhances Human Sperm Motility in a Dose and Time Dependent Manner
Seda Karabulut 1-2 Oya Korkmaz 1-2 Ceren Erdem Altun 1-2 Asuman Demiroğlu Zergeroğlu 3 İlknur Keskin 1-2
1 Istanbul Medipol University, International School of Medicine, Histology and Embryology Department, Beykoz, Istanbul, Turkey
2 Istanbul Medipol University, School of Medicine, Kavacık, İstanbul, REMER (Regenerative and Restorative Medicine Research Center) Beykoz, İstanbul, Turkey
3 Gebze Technical University, Department of Molecular Biology and Genetic, Gebze Teknik Üniversitesi Rektörlüğü 41400 Gebze, Kocaeli, Turkey
DOI : 10.23893/1307-2080.APS.05810 The aim of this study was to investigate the effect of quercetin on the motility of ejaculated human spermatozoa in asthenozoospermic cases by using different doses and exposure times. Semen samples of 94 men were incubated with quercetin at different doses and durations. Sperm motility was analysed in each group, and the results were compared. Compared to control, Quercetin improved sperm motility in each molarity and each interval except 1M. Statistically significant increase was assessed at 0.05 M after 1 hours of incubation, and 0.1 M after two hours of incubation (p<0.05). According to our results, it can be suggested that quercetin has a positive effect on sperm motility on a dose and time dependent manner. This study provides evidence for the potential use of quercetin for sperm preparation to be used in assisted reproduction techniques especially in cases of asthenozoospermia. Keywords : Sperm, motility, quercetin, asthenozoospermia

Istanbul Medipol University