ACTA Pharmaceutica Sciencia 2020 , Vol 58 , Num 2
Dose-dependent Efficacy of the N-acetylglucosamine and Quercetin Combination in Rats with Renal Failure
Sergii Shebeko 1 Igor Zupanets 1 Marina Zimina 2
1 Department of Clinical Pharmacology & Clinical Pharmacy, National University of Pharmacy, 27 Pushkinska Str., Kharkiv, Ukraine, 61057
2 Department of General Practice ? Family Medicine, School of Medicine, V. N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv, Ukraine, 61022
DOI : 10.23893/1307-2080.APS.05809 The study was devoted to the evaluation of dose-dependent efficacy of N-acetylglucosamine and quercetin combination in the treatment of renal failure. The combination was studied in injectable dosage form at the doses of 10, 20, 40 and 60 mg/kg in rats with chromium-induced nephropathy. The efficacy of combination was assessed by animal survival, renal excretory function, nitrogen metabolism and nephroprotective activity. Also, the ED50 index was calculated by Probit Analysis method. The efficacy of combination at doses of 40 and 60 mg/kg was most expressed with insignificant differences (p>0.05) between them. There was a significance increase (p<0.05) in animal survival, renal excretory function and normalization of nitrogen metabolism. This led to the nephroprotective activity of 67.8 and 70.4%, respectively. The ED50 index of combination was 30.2 ± 6.3 mg/ kg. Thus, this test combination at a dose of 30.2 mg/kg is the promising drug for experimental treatment of kidney diseases. Keywords : N-acetylglucosamine, Quercetin, Nephroprotective effect, Median effective dose, Renal failure

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