ACTA Pharmaceutica Sciencia 2020 , Vol 58 , Num 2
Antipsychotic effects of Philenoptera cyanescens (Schum. & Thonn.) Roberty (Leguminosae) Leaf Extract and Fractions against Ketamine-induced Psychosis in Mice
Mubo Adeola Sonibare 1 Isimot Temitope Arowona 1-2 Khalid Rauf 2
1 Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria
2 NeuroPharmacology Unit, Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan
DOI : 10.23893/1307-2080.APS.05808 This study investigated the antipsychotic potentials of Philenoptera cyanescens (PC) methanol extract and fractions against ketamine-induced psychosis in Balb/C mice.

The methods used were the hyper-locomotion, stereotype behaviour, Y-maze and Forced Swim Test models. The extrapyramidal effect of the active fractions was tested using the catalepsy model.

The crude extract and all fractions at varying doses significantly reduced ketamineinduced hyperactivity and stereotype behaviour with dichloromethane fraction being the most active compared with the standards. Dichloromethane and ethyl acetate fractions (250 mg/kg) reversed the cognitive impairments enhanced by ketamine at the 1st, 5th, and 10th day of the experiments and also decreased the immobility time in the FST model at 11th and 15th days post treatment. The two fractions did not induce catalepsy and also inhibited the cataleptic effect induced by haloperidol.

The results established that Philenoptera cyanescens possesses antipsychotic effect against positive, negative and cognitive symptoms of psychosis. Keywords : Philenoptera cyanescens, Antipsychotic activity, Hyper-locomotion, Stereotypy, Forced swim test

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